I've Got the Methylene Blues

 We used methylene blue to test dialyzers when I worked at Baxter-Travenol Labs in Round Lake, IL a few lifetimes ago. If I had known then when I know now, I would have been taking it daily since. Dosing is in the article. 

The article is the transcript of an interview with Scott Sherr, M.D. entitled "Methylene Blue – The Magic Blue Pill for Energy and Brain Performance." I edited this excerpt for clarity.

It is well worth your time to read, especially if you are concerned about Aging Gracefully:

“Methylene blue is one of these very unique compounds that helps you make more energy in your mitochondria which is the powerhouse, the energy production center of your cell. But at the same time, it also increases antioxidant capacity… The electron transport chain is just an energy gradient that is created in your mitochondria so that you can make energy. And what you need for that to happen are electrons. And these come from our food, but they can come from molecules like methylene blue that donate electrons to the electron transport chain, induce the gradient, which allows you to make more energy. And that is how it works. Interestingly enough, there are other things that also donate electrons to the complex four. One of the major things is red light, near-Infrared light at 660 nanometers does the same thing.”

https://bit.ly/3RHN1nP 

NAD+ Health Benefits

 A name for the 4th Baby Step in "Aging Gracefully" eludes me. The previous one is Adult Steps, but I want to go beyond it. I think "Anti-Aging Steps" could work, especially since my recommendations include cutting-edge techniques for longevity.

This then is my first entry into the 4th Step:

NAD+, or nicotinamide adenine dinucleotide, is a coenzyme that is involved in many cellular processes, such as energy metabolism, DNA repair, and immune function. NAD+ levels decline with age, and this may contribute to various age-related diseases and conditions. Some of the potential health benefits of NAD Plus are:

• It may slow down aging by activating sirtuins, a group of proteins that regulate gene expression and cellular health.

• It may increase energy by enhancing mitochondrial function, the powerhouses of the cells.

• It may improve cognitive function by protecting neurons from oxidative stress and inflammation.

• It may reduce cholesterol by modulating lipid metabolism and lowering LDL (bad) cholesterol levels .

• It may reduce cancer risk by repairing DNA damage and preventing genomic instability.

The optimal dosage of NAD+ supplements is not yet established, as different forms of NAD precursors may have different bioavailability and efficacy. However, some studies have suggested that doses ranging from 100 mg to 1000 mg per day may be effective and safe for most people. The most common forms of NAD precursors are nicotinic acid (NA), nicotinamide riboside (NR), nicotinamide (NAM), and nicotinamide mononucleotide (NMN). Each of these forms has its own advantages and disadvantages, such as side effects, cost, and absorption rate. Therefore, it is advisable to consult with a healthcare professional before taking any Niacin-related supplements.

Turmeric and Curcumin

I gotta admit that I was a turmeric hold-out for far too long. Despite the wise advice of photographer extraordinaire Leroy Skalstad, I started supplementing only this past Summer. And I am so glad I did.

I have severe osteoarthritis in my right wrist and knee, and milder OA on the left. There is a painful Morton's Neuroma hiding in my right foot. Four discs are bulging in my lower back on both side of my spine. That damned spine is also getting narrower, a condition called "spinal stenosis." That's a lot of pain to deal with, but now I rarely take any prescription pain medication. 

There are other benefits of turmeric/curcumin. Enjoy the summary and learn all about it! 

Turmeric and curcumin are widely used for their health benefits, especially for their anti-inflammatory and antioxidant properties. Here are some some of turmeric's benefits:

- Turmeric contains bioactive compounds with medicinal properties, such as curcumin, which is the main active ingredient in turmeric. Curcumin has powerful anti-inflammatory effects and is a very strong antioxidant.

- Curcumin may help reduce joint pain and inflammation in people with arthritis, as well as improve knee function and reduce NSAID usage. It works well for me. I haven't taken an NSAID in 4 months. Well, except for the daily baby aspirin.

- Curcumin may also boost memory and mood, as it can protect the brain from harmful free radicals and mitigate the effects of depression and anxiety.

- Curcumin may support heart health by improving endothelial function, which is the lining of the blood vessels. Curcumin may also lower blood pressure, cholesterol, and triglycerides.

- Curcumin may have anticancer potential, as it can modulate various molecular pathways involved in cancer development, growth, and spread. Curcumin may also enhance the effectiveness of chemotherapy and radiation therapy.

- Curcumin may help prevent or treat type 2 diabetes by improving insulin sensitivity, lowering blood sugar levels, and reducing oxidative stress and inflammation.

The optimal dose of turmeric and curcumin may vary depending on the health condition you’re trying to treat, as well as the form and quality of the supplement you’re taking. However, some general guidelines are:

- The curcumin content of turmeric is around 3% by weight, so you would need to consume a large amount of turmeric to get a significant dose of curcumin.

- Most studies use turmeric extracts that contain mostly curcumin itself, with dosages usually exceeding 1 gram per day. It would be very difficult to reach these levels just using turmeric as a spice in your foods.

- Curcumin is poorly absorbed into your bloodstream, so you need to enhance its bioavailability by consuming it with black pepper, which contains piperine. Piperine can increase the absorption of curcumin by 2,000%. Alternatively, you can look for curcumin supplements that contain piperine or other bioenhancers.

- Curcumin is also fat soluble, which means it dissolves in fat or oil. Therefore, it may be a good idea to take curcumin supplements with a meal that’s high in fat. The minimum amount of fat for optimal absorption is 15 grams. I take it with my Bulletproof coffee every morning. Usually I blend in a tablespoon of coconut/MCT oil plus one TB of butter or ghee. That's about 28 grams.

- Research suggests 500–2,000 mg of turmeric per day may have potential benefits, particularly in extract form. However, different amounts may be recommended depending on the specific health condition you’re trying to address.

- The risk of side effects is minimal but turmeric supplements are unsuitable for some people. For example, people who have gallstones or bile duct obstruction should avoid turmeric supplements, as they may worsen their condition. Turmeric supplements may also interact with certain medications, such as blood thinners or diabetes drugs. Therefore, it’s advisable to consult your doctor before taking turmeric or curcumin supplements.

If you have any questions or concerns about your health or supplement use, please talk to your doctor or a qualified health professional.